Publications

Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation. Immunity

Frank A. Buquicchio, Raissa Fonseca, Patrick K. Yan, Fangyi Wang, Maximilien Evrard, Andreas Obers, Jacob C. Gutierrez, Colin J. Raposo, Julia A. Belk, Bence Daniel, Pirooz Zareie, Kathryn E. Yost, Yanyan Qi, Yajie Yin, Katherine F. Nico, Flora M. Tierney, Michael R. Howitt, Caleb A. Lareau, Ansuman T. Satpathy, Laura K. Mackay. 2024, doi:10.1016/j.immuni.2024.06.014

Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance. Immunity

Tyler E. Billipp, Connie Fung 2, Lily M. Webeck, Derek B. Sargent, Matthew B. Gologorsky, Zuojia Chen, Margaret M. McDaniel, Darshan N. Kasal, John W. McGinty, Kaitlyn A. Barrow, Lucille M. Rich, Alessio Barilli, Mark Sabat, Jason S. Debley, Chuan Wu, Richard Myers, Michael R. Howitt, Jakob von Moltke. 2024, doi: 10.1016/j.immuni.2024.03.023.

Intestinal tuft cell immune privilege enables norovirus persistence. Science Immunology

Madison S. Strine, Eric Fagerberg , Patrick W. Darcy , Gabriel M Barrón, Renata B. Filler, Mia Madel Alfajaro, Nicole D'Angelo-Gavrish, Fang Wang, Vincent R. Graziano, Bridget L. Menasché, Martina Damo, Ya-Ting Wang, Michael R. Howitt, Sanghyun Lee, Nikhil S. Joshi, Daniel Mucida, Craig B. Wilen. 2024, doi: 10.1126/sciimmunol.adi7038.

Metabolic diversity in commensal protists regulates intestinal immunity and transkingdom competition. Cell

Elias R. Gerrick, Soumaya Zlitni, Patrick T. West, Matthew M. Carter, Claire M. Mechler, Matthew R. Olm, Elisa B. Caffrey, Jessica A. Li, Steven K. Higginbottom, Christopher J. Severyn, Frauke Kracke, Alfred M. Spormann, Justin L. Sonnenbug, Ami S. Bhatt, Michael R. Howitt. 2024, doi:10.1016/j.cell.2023.11.018.

Commensal protists in reptiles display flexible host range and adaptation to ectothermic hosts. mBio

Elias R. Gerrick, Leila B. DeSchepper, Claire M. Mechler, Lydia-Marie Joubert, Freeland Dunker, Timothy J. Colston, Michael R. Howitt. 2023, doi: 10.1128/mbio.02273-23.

Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape. PNAS

Connie Fung, Lisa M. Fraser, Gabriel M. Barrón, Matthew B. Gologorsky, Samantha N. Atkinson, Elias R. Gerrick, Michael Hayward, Jennifer Ziegelbauer, Jessica A. Li, Katherine F. Nico, Miles D. W. Tyner, Leila B. DeSchepper, Amy Pan, Nita H. Salzman, Michael R. Howitt. 2023, 120(23), e2216908120. doi:10.1073/pnas.2216908120.

The abundance and morphology of human large intestinal goblet and tuft cells during chronic schistosomiasis. Parasite Immunology

Matthew B. Gologorsky, Claire M. Mechler, Erna Forgó, Gregory W. Charville, Michael R. Howitt. 2023, e12981. doi:10.1111/pim.12981.

Succinate and tuft cells: How does this sensory process interface with food allergy? Journal of Allergy and Clinical Immunology

Katherine F. Nico, Miles D. W. Tyner, Michael R. Howitt. 2022, 150(3), 580-582.

A Tuft Act to Follow: Leukotrienes Take the Stage in Anti-worm Immunity. Immunity

Connie Fung, Michael R. Howitt. 2020, 52(3), 426-428.

The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis. Immunohorizons

Michael R. Howitt, Y. Grace Cao, Matthew B. Gologorsky, Jessica A. Li, Adam L. Haber, Moshe Biton, Jessica Lang, Monia Michaud, Aviv Regev and Wendy S. Garrett. 2020, 4 (1) 23-32

Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science

Wilen, C. B., Lee, S., Hsieh, L. L., Orchard, R. C., Desai, C., Hykes, B. L., McAllaster, M. R., Balce, D. R., Feehley, T., Brestoff, J. R., Hickey, C. A., Yokoyama, C. C., Wang, Y. T., MacDuff, D. A., Kreamalmayer, D., Howitt, M. R., Neil, J. A., Cadwell, K., Allen, P. M., Handley, S. A., van Lookeren Campagne, M., Baldridge, M. T., Virgin, H. W. 2018; 360 (6385): 204–8

A single-cell survey of the small intestinal epithelium. Nature

Haber, A. L., Biton, M., Rogel, N., Herbst, R. H., Shekhar, K., Smillie, C., Burgin, G., Delorey, T. M., Howitt, M. R., Katz, Y., Tirosh, I., Beyaz, S., Dionne, D., Zhang, M., Raychowdhury, R., Garrett, W. S., Rozenblatt-Rosen, O., Shi, H. N., Yilmaz, O., Xavier, R. J., Regev, A. 2017; 551 (7680): 333–39

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science

Howitt, M. R., Lavoie, S., Michaud, M., Blum, A. M., Tran, S. V., Weinstock, J. V., Gallini, C. A., Redding, K., Margolskee, R. F., Osborne, L. C., Artis, D., Garrett, W. S. 2016; 351 (6279): 1329-1333

Helicobacter pylori CheZHP and ChePep form a novel chemotaxis-regulatory complex distinct from the core chemotaxis signaling proteins and the flagellar motor. Molecular microbiology

Lertsethtakarn, P., Howitt, M. R., Castellon, J., Amieva, M. R., Ottemann, K. M. 2015; 97 (6): 1063-1078